Renewal of the seven acre estate will provide 1,176 houses, shops, healthcare and community facilities over 12 years, with work divided into six phases.
Outline planning consent has now been granted for the mixed-use scheme, with detailed planning approval also given to start the £40m phase one to build 342 new homes, together with retail space, at the eastern end of Aberfeldy.
Willmott Dixon will carry-out construction work, the largest development project undertaken by Regen.
Chief executive Andrew Telfer said: “This is a mammoth undertaking that will provide an exciting future for Aberfeldy estate’s residents as well as enticing a new generation of people looking to benefit from the region’s Olympic legacy and its quick links into Docklands and the City.
“Taking our regeneration experience of similar estates in other parts of London, we are pleased to be working with Poplar HARCA which is a strong and well established presence in this part of east London.”